Bayer Cropscience S.a.

Bayer Cropscience Gmbh

Mehul Rasikchandra Amin

Peter Dominic Riordan

Norman Dann

Timothy Jackson

Manuel Vangelisti

Robert Pannell

Disclosed herein is a process for the preparation of a compound of the formula (II): or a salt thereof, wherein X is halogen; each Y, which may be the same or different, is halogen, haloalkyl, alkoxycarbonyl or alkylsulphonyl, and n is 0 to 3;which process comprises treating a compound of the formula (III): with a cyanide source and a catalyst selected from the group consisting of a tetraalkyl ammonium salt and a tetraalkyl phosphonium salt in an aqueous solvent or without solvent, wherein:X is halogen; each Y, which may be the same or different, is halogen, haloalkyl, alkoxycarbonyl or alkylsulphonyl: and n is 0 to 3; and wherein the cyanide source is hydrogen cyanide, an alkali metal cyanide, an alkaline earth metal cyanide or an optionally substituted ammonium cyanide.

Processes for the preparation of 2-aminomethylpyridines and the 2-cyanopyridines used in their preparation

Process for the preparation of 2-aminomethylpyridine derivative of general formula (I), in which: n represents 0, 1, 2 or 3; X is halogen atom; Y may be the same or different and may be a halogen atom, a halogenoalkyl, a alkoxycarbonyl or a alkylsulphonyl 

Process for the preparation of 2-aminomethylpyridine derivative

The invention relates to a process for the preparation of a compound of formula (V), according to the following scheme: wherein the various substituants are as defined in the description

Processes for the preparation of 2-aminomethlpyridines and the 2-cyanopyridines used in their preparation

Process for the preparation of 2-cyanopyridines

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Suffolk, United Kingdom

Mehul Rasikchandra Amin