Leland Stanford Junior University

Mehrdad Shamloo

Michael J Green

Alam Jahangir

Bitna Yi

William C Mobley

Tina M Cowan

Gregory M Enns

Rolando E Yanes

Pooneh Memar Ardestani

Tereza Moore

Andrew Kelley Evans

Mehrdad Faizi

Methods of treatment and pharmaceutical formulations configured to treat primary and secondary mitochondrial dysfunction are provided. The methods and treatments use an agonist of AMPK. The agonist activates AMPK to activate ATP-producing pathways and inhibiting ATP-consuming pathways, thus allowing for the alleviation of symptoms associated with mitochondrial dysfunctions.

Methods and formulations to treat mitochondrial dysfunction

Adrenergic receptor modulating compounds and methods of using the same are provided. Also provided are methods of treating a subject for a disease or condition associated with an adrenergic receptor including administering a therapeutically effective amount of the subject compound. Aspects of the disclosure include a method of modulating an inflammatory pathway in a cell, such as the production of TNF-alpha in the cell. The method can include contacting a cell with &#x3b2;1-selective adrenergic receptor modulating compound to selectively activate a cAMP pathway over a beta-arrestin pathway in the cell. Pharmaceutical compositions and kits which include the subject compounds are provided.

Adrenergic receptor modulating compounds and methods of using the same

A &#x3b2;-ADR agonist prodrug compound, which is hydrolysable in vivo to release a &#x3b2;1-ADR agonist compound, and which prodrug compound contains a group which imparts greater lipophilicity and CNS bioavailability to the prodrug compound relative to the &#x3b2;1-ADR agonist compound.

Method of improving cognition and social behavior in humans having deficits therein due to neurodegenerative disorders and compounds and compositions therefor

A method for enhancing learning or memory of both in a mammal having impaired learning or memory of both from a neuro-degenerative disorder, which entails the step of administering at least one compound or a salt thereof which is a &#x3b2;-adrenergic receptor agonist, partial agonist or receptor ligand in an amount effective to improve the learning or memory or both of said mammal.

Method for enhancing learning and memory impaired by neurodegenerative disorders and compounds and compositions for effecting the same

Growing community of inventors

Stanford, CA, United States of America

Mehrdad Shamloo