Boehringer Ingelheim Pharmaceuticals, Inc.

Mehran Yazdanian

Barbara Jean Bormann

A brain microvessel endothelial cell having a Middle-T antigen gene from papovirus is disclosed. The brain microvessel endothelial cell exhibits normal cell phenotype, maintains the phenotype in culture and forms monolayers substantially impermeable to low molecular weight molecules. The cells are useful for in vitro studies involving the blood brain barrier. Also disclosed, are methods of using and processes of making these cells.

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Danbury, CT, United States of America

Mehran Yazdanian