Bioptigen, Inc.

Leica Microsystems Inc.

Optopo Inc.

Mehran Ghofrani

Christopher E Saxer

Al-Hafeez Z Dhalla

Eric L Buckland

Robert H Hart

Nestor O Farmiga

Andrew Murnan

Prasant Potuluri

Evan Christopher Cull

John Edward Stranzl, Jr

A scanning optical system is provided including a source of optical radiation; an optical scanning beam delivery system for delivering optical radiation to a subject, wherein the optical scanning beam delivery system includes a plurality of optical elements including at least one steerable mirror; at least one actuator coupled to the at least one steerable mirror; a detection system for detecting optical radiation returned from a subject; a communications device including a user interface and configured to process a set of instructions at least partially responsive to inputs from the user interface; a controller comprising memory, a microcontroller and an field programmable gate array (FPGA), the microcontroller and FPGA receiving instructions derived from the communications device; and at least one actuator coupled to the at least one steerable mirror. The at least one actuator receives a first instruction set from the microcontroller in the form of sequential commands and a second instruction set from the FPGA in the form of concurrent commands. The first instruction set establishes a pattern of motion of the at least one steerable mirror at least partially responsive to inputs from the user interface of the communications device. The second instruction set modifies an attribute of the pattern of motion of the at least one steerable mirror in substantially real-time at least partially responsive to one or more triggering events.

Configurable optical beam scan drive sytems

An optical coherence tomography (OCT) system including a source of broadband optical radiation and a beamsplitter coupled to the source is provided. The beamsplitter divides the source radiation into a reference path and a sample path. The reference path includes an optical switch to switch the reference path between a first path having a first reference reflection at a first reference optical path length and a second path having a second reference reflection at a second reference optical path length. The system further includes a beam combiner that mixes source radiation reflected from a subject in the sample path with source radiation returned from the first reference reflection and the second reference reflection. A detection system detects a first wavelength dependent interferogram during the first time interval and a second wavelength dependent interferogram during the second time interval. A processor preconditions the first and second wavelength dependent interferograms.

Image registration, averaging, and compounding for high speed extended depth optical coherence tomography

An optical coherence tomography (OCT) system including a source of broadband optical radiation and a beamsplitter coupled to the source is provided. The beamsplitter divides the source radiation into a reference path and a sample path. The reference path includes an optical switch to switch the reference path between a first path having a first reference reflector at a first reference optical path length and a second path having a second reference reflector at a second reference optical path length, different from the first reference optical path length. The system further includes a beam combiner that mixes source radiation reflected from a subject in the sample path with source radiation returned from the first reference reflector during a first time interval and the second reference reflector during a second time interval. A detection system detects a first wavelength dependent interferogram during the first time interval and a second wavelength dependent interferogram during the second time interval. A processor preconditions the first and second wavelength dependent interferograms; multiples the first preconditioned wavelength dependent interferogram and the second preconditioned wavelength dependent interferogram; and computes a first A-scan from the first wavelength dependent interferogram; a second A-scan from the second wavelength dependent interferogram; a spatial offset between the first and second A-scans derived from the multiplicative product of the preconditioned first and second wavelength dependent interferograms; and a combined A-scan from the first and second A-scans.

The static MMS spectral reconstruction process is optimized using algorithmic methods. Because the static MMS encodes spectral information across the detector plane in a highly non-local way, optical errors have a non-local effect on the reconstruction which introduces noise and errors at regions throughout the spectral range. Mathematical signal processing techniques are used to condition and deconvolve the spectral image to compensate for non-ideal system behavior. Spectral signal-to-noise and accuracy are both improved, while the inherent resolution and etendue advantages of the static MMS technique are retained.

Method and apparatus for reconstructing optical spectra in a static multimode multiplex spectrometer

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Cary, NC, United States of America

Mehran Ghofrani