Celera Corporation

Amgen Fremont Inc.

Mehdi Mesri

Steve Ruben

Charles E Birse

Paul A Moore

Gregory M Landes

Tao He

Candy Lee

Michael Jeffers

Marcia Lewis

Elizabeth Joseloff

Karen Van Orden

Binyam Bezabeh

Nikolia Khramtsov

Gary Starling

Francine Chen

Charles Birse

Marica Lewis

Kam Fei Tse

Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods.

Lung cancer markers and uses thereof

Lung cancer markers, and uses thereof

Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (CAT). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.

Methods and compositions for diagnosing and treating diseases

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North Potomac, MD, United States of America

Mehdi Mesri