Pharmajor International

Laboratoires Major

Duo-ge

Mehdi El Glaoui

Guillaume El Glaoui

Philippe Perrin

Stéphane Droupy

Véronique Agathon-Meriau

Jean Hoffelt

Jean-Pierre Fontaine

The present invention relates to non-hormonal compositions and methods for inducing a condition of aspermia, azoospermia, or severe oligozoospermia in the male subject such that these compositions and methods for administering the same may be used as male contraception. Embodiments of the present invention may comprise a composition comprising an alpha-1-adrenoreceptor antagonist, such as (R)-silodosin, for daily administration to a male subject. The compositions and related methods may further include pharmaceutically acceptable carriers. The present invention further includes formulations which allow for a delay such that delayed or missed dose(s) do not nullify the contraceptive effect of the treatment regimen. Such compositions and methods may also avoid the side effects associated with typical formulations of alpha-1-adrenoreceptor antagonists.

Non-hormonal compositions and methods for male contraception

The device () according to the invention aims to join at least two medicine capsules (A, B) by adhesive bonding in a reliable and economical manner, in particular in the context of industrial production. To do this, this device comprises at least one matrix (), which at least partially delimits a recess (), for depositing capsules (Eight, B), and also a chamber (), this recess and this chamber being separated from each other by a deformable wall () of the matrix, which matrix is designed to move elastically, by pneumatic action of its chamber (), from a first configuration, in which its recess () receives the capsules with a glue (Z) interposed between them, to a second configuration, in which its deformable wall () at least partially envelops the capsules by flexible deformation, in such a way as to at least partially enclosed these capsules between the deformable wall and a bottom of the recess in order to align them and press them against one another.

Device and installation for joining at least two medicine capsules by adhesive bonding

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Paris, France

Mehdi El Glaoui