Silverbrook Research Pty Ltd

Geneasys Pty Ltd

Zamtec Limited

Other

Mehdi Azimi

Kia Silverbrook

Samuel George Mallinson

Angus John North

Matthew Taylor Worsman

Gregory John McAvoy

Paul Justin Reichl

Alireza Moini

Jennifer Mia Fishburn

Geoffrey Richard Facer

Gregory John Mcavoy

A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing target nucleic acid sequences, hybridization chambers containing probes that each have a nucleic acid sequence for hybridization with the target nucleic acid sequences to form probe-target hybrids, a fluorophore and a quencher configured such that the fluorophore emits a fluorescence signal in response to an excitation light and the quencher quenches the fluorescence signal when the probe is not hybridized, but fails to quench the fluorescence signal from the probe-target hybrid, and, a calibration chamber with no fluorophore.

Genetic analysis LOC with hybridization array with calibration chamber containing probe that lacks a reporter

A microfluidic test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing configured for hand-held portability, the outer casing having an inlet for receiving the fluid containing the target nucleic acid sequences, a hybridization chamber mounted in the casing, the hybridization chamber containing electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the ECL probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and electrodes for receiving an electrical pulse to excite the ECL luminophores, wherein, the hybridization chamber has a volume less than 900,000 cubic microns.

Microfluidic test module with low-volume hybridization chambers for electrochemiluminescent detection of target nucleic acid sequences in a fluid

A microfluidic thermal bend actuated pressure pulse valve having an inlet for receiving a flow of liquid, an outlet for outputting the flow of liquid, a meniscus anchor between the inlet and the outlet such that the flow from the inlet towards the outlet stops at the meniscus anchor where the liquid forms a meniscus, a movable member for contacting the liquid, and, a thermal expansion actuator for displacing the movable member to generate a pulse in the liquid to dislodge the meniscus such that the liquid flow towards the outlet resumes.

Microfluidic thermal bend actuated pressure pulse valve

A test module for excitation of electrochemiluminescent probes configured to detect target nucleic acid sequences, the test module having an outer casing having a receptacle for receiving a fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for receiving an electrical pulse to excite the ECL luminophores, a detection photosensor for exposure to the photons emitted by the ECL luminophores, control circuitry providing the electrical pulse to the electrodes, and, a universal serial bus (USB) connection such that the outer casing is configured as a USB drive for transmitting data regarding detection of the targets in the fluid to an external device, wherein during use, the ECL probes that have detected one of the target nucleic acid sequences reconfigure such that the functional moiety does not quench the photon emission from the ECL luminophore when excited by the electrodes.

USB-interfaceable portable test module for electrochemiluminescent detection of targets

A lab-on-a-chip (LOC) device having a supporting substrate, a sample inlet for receiving a fluid sample, an incubation section in fluid communication with the sample inlet, the incubation section having at least one heater, and, CMOS circuitry between the supporting substrate and the incubation section, wherein, the CMOS circuitry is connected to the at least one heater for maintaining the fluid sample at an incubation temperature for an incubation period.

LOC device with on-chip semiconductor controlled incubation section

A microfluidic test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing having an inlet for receiving the fluid containing the target nucleic acid sequences, electrode pairs for receiving an electrical pulse, electrochemiluminescent (ECL) probe spots in contact with each of the electrode pairs respectively, the ECL probe spots containing ECL probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, such that the electrical pulse to the electrode pair excites the ECL luminophores, wherein, the mass of the ECL probes in each of the probe spots is less than 270 picograms.

Microfluidic test module with low mass electrochemiluminescent probe spots

A portable test module for excitation of electrochemiluminescent probes configured to detect target nucleic acid sequences, the test module having an outer casing configured for hand-held portability, the outer casing having a receptacle for receiving a fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and, electrodes for receiving an electrical pulse to excite the ECL luminophores, wherein during use, the ECL probes that have detected one of the target nucleic acid sequences reconfigure such that the functional moiety does not quench the photon emission from the ECL luminophore when excited by the electrodes.

Portable test module for excitation of electrochemiluminescent probes

A test module for performing a genetic diagnostic assay, the test module having an outer casing dimensioned for hand-held portability, the outer casing having a receptacle for a biological sample containing target nucleic acid sequences, an array of chambers containing probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, a flow-path extending from the inlet to the probes, and, a reagent reservoir containing a reagent for addition to the sample in the flow-path upstream of the probes, wherein, each of the chambers contains less than 270 picograms of probe and the reagent reservoir has a volume less than 1000,000,000 cubic microns.

Genetic test module with low oligonucleotide probe mass and reagent volumes

A test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing having a receptacle for receiving the fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for receiving an electrical pulse to excite the ECL luminophores, and, a detection photosensor for exposure to the photons emitted by the ECL luminophores.

Test module with integral photosensor for electrochemiluminescent detection of hybridization

A fluid sensor for detecting fluid in a chamber, has a MEMS sensing element of conductive material with a resistance that is a function of temperature, and electrical contacts for connection to an electrical power source for heating the sensing element with an electrical signal, so that control circuitry can measure the current passing through the sensing element during heating of the sensing element; and determine the temperature of the sensing element from the known applied voltage, the measured current and the known relationship between the current, resistance and temperature. As the temperature of the element will be greater if it is in the presence of gas rather than liquid, the sensor determines if there is liquid or gas in the chamber. This is particularly useful to detect if the chambers of an inkjet printhead are primed with ink.

MEMS fluid sensor

A test module for biochemical processing and analysis, the test module having an outer casing dimensioned for hand-held portability, the outer casing having a receptacle for receiving biochemical liquid, and, a reagent reservoir containing a reagent for addition to the biochemical liquid for use in chemical analysis of the biochemical liquid, wherein, the reagent reservoir has a volume less than 1000,000,000 cubic microns.

Test module with low-volume reagent reservoir

A test module for concentrating pathogens in a biological sample, the test module having an outer casing with a receptacle for receiving the sample, a dialysis device in fluid communication with the receptacle and configured to separate the pathogens from other constituents in the sample, and, a lab-on-a-chip (LOC) device being in fluid communication with the dialysis device and configured to analyze the pathogens.

Test module with microfluidic device having LOC and dialysis device for separating pathogens from other constituents in a biological sample

An inkjet nozzle assembly has a chamber with a nozzle opening for ejecting a liquid, a heater element disposed in the chamber, and a dielectric layer sandwiched between the heater element and a wall of the chamber. The dielectric layer has a thermal product of less than 1495 JmKs. The thermal product is defined as (&#x3c1;Ck), where &#x3c1; is the density of the layer, C is specific heat of the layer and k is thermal conductivity of the layer.

Inkjet nozzle assembly having heater element bonded to chamber wall via dielectric layer

Provided is an inkjet printhead having an array of ink chambers formed on a planar support surface of a wafer substrate. Each ink chamber in the array has a nozzle, a thermal actuator for ejecting ink through the nozzle and a droplet stem anchor. The thermal actuator has two sections with higher resistance than the remainder of the thermal actuator. The droplet stem anchor is positioned between the two sections with higher resistance of the thermal actuator.

Ink chamber with droplet step anchor

An inkjet printer that has an array of ink chambers, each with a nozzle, a droplet stem anchor and a thermal actuator. The thermal actuator generates a vapor bubble in the ink chamber to eject ink through the nozzle. The thermal actuator has a plurality of heater elements connected in parallel with a cross bracing structure extending between the heater elements. The cross bracing structure also providing the droplet stem anchor. During use, the vapor bubble generated by the thermal actuator grows until it vents to atmosphere through the nozzle and the ink ejected from the nozzle is attached to the droplet stem anchor by an ink stem until the stem breaks and the ejected ink forms a separate drop.

Growing community of inventors

Balmain, Australia

Mehdi Azimi