Tokyo Institute of Technology

Denka Company Limited

The Kitasato Institute

Director-general of National Institute of Infectious Diseases

Megumi Mano

Kazuhiko Katayama

Yoshimasa Takahashi

Motohiro Miki

Takafumi Ueno

Reiko Todaka

Kengo Yoshikawa

Taishi Onodera

The present invention addresses the issue of providing a norovirus component vaccine for subcutaneous, intradermal, percutaneous, or intramuscular administration which vaccine can readily immunize the target cells, an associated product of a molecular needle serving as an active ingredient of the vaccine, and a production method for the associated product. The invention provides a norovirus component vaccine containing, as an active ingredient, an associated product including a hexamer formed through bonding of two molecules of a trimer of a molecular needle represented by the following formula (1). W-L-X&#x2014;Y (1) [wherein W represents an amino acid sequence of P domain of the capsid protein of norovirus as an immunogen; Lrepresents a first linker sequence having 0 to 100 amino acids; X represents an amino acid sequence represented by SEQ ID NO: 1; Y represents an amino acid sequence of a cell introduction domain; n is an integer of 1 to 3].

Composite polypeptide monomer, aggregate of said composite polypeptide monomer having cell penetration function, and norovirus component vaccine for subcutaneous, intradermal, percutaneous, or intramuscular administration and having said aggregate as effective component thereof

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Tokyo, Japan

Megumi Mano