National Institutes of Health, a Component of the US Dept. of Health & Human Services

Loyola University of Chicago

Meghan J Orr

Wei Ping Zheng

Wenwei Huang

Philip Edward Sanderson

Xiuli Huang

Gregory J Tawa

Kim C Williamson

Hao Li

Paresma R Patel

Hangmao Sun

Xiao Lu

Myunghoon Kim

Wei Sun

Disclosed are compounds of formula (I) and formula (II): wherein R, R, A, and B are as defined herein. Also disclosed is a method of blocking transmission of aparasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.

Compounds and method for blocking transmission of malarial parasite

Disclosed are compounds of formula (I) and formula (II): (I) (II) wherein R, R, A, and B are as defined herein. Also disclosed is a method of blocking transmission of aparasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat. 

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Chicago, IL, United States of America

Meghan J Orr