Vertex Pharmaceuticals, Inc.

Meghan Elise Cockerill

Jian Jim Wang

Albert Charles Pierce

Francois Maltais

Robert J Davies

Huai Gao

Emanuele Perola

Jingrong Cao

Anne-Laure Grillot

Wenxin Gu

James A Henderson

Yusheng Liao

David Messersmith

Ronald Lee Grey, Jr

Philip N Collier

Michael Paul DeNinno

Sanjay Shivayogi Magavi

Joshua Syken

James Daniel Frantz

Elizabeth Jin-Sun Ryu

Elisabeth Doyle

Brian Anthony Goldman

Adrianne Lynn Kolpak

Raul Eduardo Krauss

Raul Eduardo Krauss Irarrazaval

The invention relates to triazole compounds of formula I and I' or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases:  The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.

Triazoles for the treatment of demyelinating dieases

The invention relates to triazole compounds of formula I and I' or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.

Triazoles for the treatment of Demyelinating Diseases

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Boston, MA, United States of America

Meghan Elise Cockerill