Proteostasis Therapeutics, Inc.

Kineta, Inc.

Megan Foley

Bradley Tait

Matthew Cullen

Markus Haeberlein

Benito Munoz

Cecilia M Bastos

Sheila Irene Hauck

Bolin Geng

Sheila Hauck

Robert J Chambers

The present invention is directed to compounds having the Formulae (Ia-Ie), (II), (IIIa-IIId), (IVa-IVc), (Va-Vb), (VIa-VIe), (VII), (VIIIa-VIIIc), and (IX), pharmaceutically acceptable salts, prodrugs and solvates thereof, compositions of any of thereof and methods for the treatment of a condition associated with a dysfunction in proteostasis comprising an effective amount of these compounds.

Proteostasis regulators

The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, and methods for the treatment of a condition associated with a dysfunction in proteostasis.

Proteasome activity enhancing compounds

The present invention is directed to compounds that inhibit Usp14, compositions thereof, and methods for the treatment of a condition associated with a dysfunction in proteostasis.

The present invention is directed to compounds having the Formula (I), (Ia) or (Ib), compositions thereof and methods for the treatment of a condition associated with a dysfunction in proteostasis.

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Cambridge, MA, United States of America

Megan Foley