Genelabs Technologies, Inc.

Qiagen Redwood City, Inc.

Megan E Laurance

Thomas W Bruice

Albert W Tam

Douglas B Starr

Kirk E Fry

Jungsuh P Kim

Cynthia A Edwards

Mark Douglas Velligan

Emil F Michelotti

Yan Kwok

Derek R Latour

Rita L Thomas

Ana Kongpachith

Liana T Sheppard

Moon Young Lim

Moon Young Kim

The invention provides computer systems and methods for visualization and analysis of relationships between biological data.

Methods and systems for biological data analysis

Method for biological data analysis

The present invention provides molecular switch system methods and compositions for use in regulatable gene expression. The system includes a nucleic acid construct which has a DNA response sequence for a transcriptional regulatory protein operably linked to a promoter, a compound binding sequence in the vicinity of the DNA response sequence, a transgene under the control of the promoter; and a DNA binding compound. In some cases, the molecular switch system further includes a nucleic acid sequence encoding a transcriptional regulatory protein operably linked to a second promoter. The invention further provides a method for screening compounds for the ability to function in the molecular switch system and thereby regulate gene expression.

DNA binding compound-mediated molecular switch system

This invention provides nucleic acid sequences, vectors and host cells comprising regulatory regions associated with various promoters including a cyclin D1 promoter, a CD40L promoter, three HBV promoters (core, pre-S1 and HBV-X), a vancomycin-resistant enterococci (VRE) promoter, an androgen receptor promoter, a Her2 promoter, and &#x3b2;-lactamase promoter. The invention further provides methods of regulating gene expression comprising the regulatory regions of such promoters.

Promoters for regulated gene expression

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San Francisco, CA, United States of America

Megan E Laurance