University of South Florida

Ponce Health Sciences University

Meera Nanjundan

Gordon B Mills

Idhaliz Flores

Dawn Smith

Kyle A Bauckman

Provided herein are methods of treating and/or preventing endometriosis or symptom thereof, assays for diagnosing/prognosing endometriosis, compositions and formulations for treating and/or preventing endometriosis or symptom thereof, and populations of endometiotic cells, including life-extended populations of cells.

Compositions and methods for treating endometriosis

Genomic analysis of ovarian cancers demonstrated a regional chromosomal increase in expression and gene duplication. TGF-&#x3b2; stimulation indicated a link between SnoN RNA and TGF-&#x3b2;. In TIOSE, SnoN protein levels were reduced 15 min post TGF-&#x3b2;-stimulation, likely by proteosome-mediated degradation. SnoN inhibition decreased cell growth between 20 and 50% concurrent with increased p21 levels. Stable expression of SnoN led to growth arrest through induction of senescence. Collectively, these results implicate SnoN levels in multiple roles during ovarian carcinogenesis: promoting cellular proliferation in ovarian cancer cells and as a positive mediator of cell cycle arrest and senescence in non-transformed ovarian epithelial cells.

Growing community of inventors

Tampa, FL, United States of America

Meera Nanjundan