Aurobindo Pharma Limited

Meenakshisunderam Sivakumaran

Ramesh Dandala

Vijay Kumar Handa

Divvela Venkata Naga Srinivasa Rao

Sonny Sebastian

Vipin Kumar Kaushik

Arun Kumar Gupta

Umashankar Das

Divvela Venkata Naga Srinvasa Rao

Dandala Subramanyam

Sanapureddy Jagan Mohan Reddy

Koilpillai Joseph Prabahar

Uthira Kumar

Gollapalli Venkateswara Rao

Venkataiah Sunku

The present invention relates to an improved process for the preparation of pure Finasteride of Formula I, which comprises converting dihydrofinasteride to finasteride through novel protected dihydrofinasteride and protected finasteride intermediates.

Process for the preparation of pure Finasteride

The present invention is directed to a new process of preparing highly pure Florfenicol. The invention is further directed to new oxazolidine derivatives useful in making Florfenicol and processes of making these derivatives. Examples of such intermediates include (4R,5R)-3-acetyl-2,2-dimethyl-4-hydroxymethyl-5-[4-(methylsulfonyl)phenyl]-1,3-oxazolidine; and (4S,5R)-3-acetyl-2,2-dimethyl-4-fluoromethyl-5-[4-(methylsulfonyl)phenyl]-1,3-oxazolidine.

Process for preparing florfenicol

The present invention describes an industrially advantageous process to prepare highly pure 1-Methyl-3-phenylpiperazine of Formula Ithat makes use of a novel piperazine derivative, 4-Benzyl-1-methyl-2-oxo-3-phenylpiperazine, represented by Formula II1-Methyl-3-phenylpiperazine is a useful intermediate in the preparation of antidepressant Mirtazapine.

Process for preparing 1-methyl-3-phenylpiperazine using a novel intermediate

This invention relates to a novel process to obtain highly pure 4-(cyclopropylcarbonyl)-&#x3b1;,&#x3b1;-dimethylphenylacetic acid of Formula I through crystallization from a mixture of para and meta regioisomers of Formula I and II in cyclohexane, whereby the amount of undesired meta isomer, 3-(cyclopropylcarbonyl)-&#x3b1;,&#x3b1;-dimethylphenylacetic acid of Formula IIis decreased to below 0.5%. The compound of Formula I is a key intermediate for the preparation of high purity terfenadine carboxylate, which is a known antihistaminic.

Process for the preparation of a highly pure pharmaceutical intermediate, 4-(cyclopropylcarbonyl)-&#x3b1;, &#x3b1;-dimethylphenylacetic acid

Process for lactonization to produce highly pure simvastatin

Process for lactonization to produce simvastatin

The present invention relates to an industrially advantageous method for the purification of Citalopram (Formula I) wherein desmethyl citalopram (Formula II), present in crude Citalopram as an impurity, is methylated to produce pure Citalopram. The resulting Citalopram product is isolated as the base or a pharmaceutically acceptable salt thereof

Preparation of pure citalopram

A process is disclosed for the preparation of 7-amino-3-(2-furanylcarbonylthiomethyl)-3-cephem-4-carboxylic acid (also known as Furaca). The process comprises of the steps of reacting 7-aminocephalosporanic acid with a mixture of 2-thiofuric acid and Boron Trifluoride in a solvent and precipitating Furaca as a solid.

Process for the preparation of furaca

A novel process for the preparation of ceftiofur, a cephalosporin antibiotic useful in the treatment of bovine respiratory disease using a novel bromo or chloro intermediate. the process comprises of the steps of cyclizing a new bromo or chloro intermediate with thiourea in the presence of selected solvents to produce ceftiofur of high purity. A process to prepare such novel bromo and chloro intermediate comprising of the steps of condensing silylated Furaca with 4-(bromo or chloro)-2 methoxyamino-3-oxobutyric acid or its acid halide is also described.

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Hyderabad Telangana, India

Meenakshisunderam Sivakumaran