Mogam Institute for Biomedical Research

Mogam Biotechnology Institute

Mee Sook Oh

Yong Jae Kim

Seung-Hoon Lee

Jin-Hyun Park

Eui-Cheol Jo

Seongtae Yun

Heechun Kwak

Sumin Lee

Injae Oh

Jung-Seob Kim

Jae Hwan Ryu

So Ra Kim

A chimera protein according to the present application has a significantly increased in vivo half-life when administered because of a vWF domain coupled to FVIII, such that when used as a hemophilia A therapeutic agent, convenience for patients can be increased and medical expenses can be reduced.

Chimera protein comprising FVIII and vWF factors, and use thereof

Provided is an expression vector having an improved ability to express a gene. Also provided are cells transformed by the expression vector and a method for mass-producing a target protein by using the cells. The expression vector contains a simian virus 40 promoter, a scaffold attachment region or matrix attachment region element, and a chimeric intron. The vector shows an improved ability to express a gene, and thus, can attain a significantly increased expression of a heterogeneous gene.

Expression vector for expressing heterogeneous gene

Growing community of inventors

Yongin-si, South Korea

Mee Sook Oh