Glaxosmithkline LLC

Glaxo Group Limited

Glaxosmithkline Intellectual Property (no.2) Limited

Glaxosmithkline Intellectual Property Development Limited

Glaxosmithkline Intellectual Property Limited

Meagan B Rouse

William Henry Miller

Mark Andrew Seefeld

Neil W Johnson

Xinrong Tian

Kenneth Allen Newlander

Steven David Knight

Stuart Paul Romeril

Sharad Kumar Verma

Joelle Lorraine Burgess

Louis Lafrance

Dirk Andries Heerding

Dominic Suarez

Seth Wilson Grant

James Brackley, Iii

Louis Vincent Lafrance, Iii

Celine Duquenne

Dennis Shinji Yamashita

Jiri Kasparec

Simon Peace

Kenneth C McNulty

Louis Vincent Iii Lafrance

Herein are disclosed indoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Indoles

This invention relates to the use of cyclopropylamine derivatives for the modulation, notably the inhibition of the activity of Lysine-specific demethylase 1 (LSD1). Suitably, the present invention relates to the use of cyclopropylamines in the treatment of cancer.

Cyclopropylamines as LSD1 inhibitors

Herein are disclosed azaindazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Azaindazoles

Herein are disclosed indazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Indazoles

Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

Inhibitors of AkT activity

Inhibitors of Akt activity

Invented are novel pyrazole compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

Naphthyridine and quinoline derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.

Antibacterial agents

Naphthyridine and related derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.

Growing community of inventors

Collegeville, PA, United States of America

Meagan B Rouse