King Abdulaziz University

Md Nasrul Hoda

Muhammad Hussain Al-Qahtani

Syed Kashif Zaidi

Farid Ahmed

Heba Al Khatabi

Stroke patients with comorbidities, such as diabetes, hypertension, or other conditions associated with cardiovascular, pulmonary or renal disease do not respond well to current treatments for stroke. An inhibitor of S-nitrosoglutathione reductase (GSNOR) is administered as an adjunct therapy with remote ischemic conditioning (RIC) to treat a stroke in a subject having at least one comorbidity, such as diabetes and hypertension. When performed in conjunction with GRI therapy and RIC, intravenous tissue plasminogen activator therapy (IVT) for thrombolysis and/or endovascular thrombectomy (EVT) for clot retrieval are effective in subjects with comorbidities, even after five hours post-onset of stroke.

GSNO reductase inhibitor as an adjunct therapy in cerebral thrombosis and/or thromboembolic stroke

GSNO reductase inhibitor as an adjunct therapy with remote ischemic conditioning and thrombolytic reperfusion therapies in stroke

GSNO reductase inhibitor as an adjunct therapy with remote ischemic conditioning and thrombolytic reperfusion therapies in cerebral thrombosis and/or thromboembolic stroke

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Jeddah, Saudi Arabia

Md Nasrul Hoda