Tel Aviv University

Bar-Ilan University

Biolinerx Ltd.

Mazal Shaul

Ada Rephaeli

Irit Gil-Ad

Abraham Weizman

Efrat Halbfinger

An acid addition salt of a nortriptyline-GABA conjugate, a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate, and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms of a nortriptyline-GABA conjugate in the treatment of CNS disorders, and in the treatment of pain in particular, are also disclosed. Further disclosed in a large-scale process of preparing a nortriptyline-GABA conjugate.

Acid addition salt of a nortriptyline-GABA conjugate and a process of preparing same

Novel crystalline form of perphenazine 4-aminobutyrate trimesylate and a process of producing the same are disclosed. The novel crystalline form is characterized by a unique XRPD pattern and a DSC that exhibits an endothermic peak at a relatively high temperature (e.g., higher than 209&#xb0; C.). Also disclosed are a process of preparing perphenazine 4-aminobutyrate trimesylate by in situ deprotection and salification, in a single-step synthesis, and a highly pure perphenazine 4-aminobutyrate trimesylate obtained thereby. Uses of any of the described perphenazine 4-aminobutyrate trimesylate are also disclosed.

Crystalline forms of the tri-mesylate salt of perphenazine-GABA and process of producing the same

Growing community of inventors

Azur, Israel

Mazal Shaul