Kyowa Hakko Kogyo Co., Ltd.

Other

Mpi Corporation

Kyowa Hakko Kabushiki Kaisha

Mayumi Yoshida

Katsuhiko Ando

Isao Kawamoto

Yuzuru Matsuda

Takeo Tanaka

Kenji Shibata

Motoo Yamasaki

Keiichi Yano

Kazuo Yamaguchi

Eiji Tsukuda

Toshiyuki Suzawa

Shigeto Kitamura

Shigeru Chiba

Isami Takahashi

Tatsuhiro Ogawa

Yoshikazu Morishita

Chieko Bando

Mika Makino

Toshihide Ikemura

Hirofumi Nakano

Eiji Kobayashi

Tatsuya Tamaoki

Hiroshi Sano

Yutaka Saito

Shiro Akinaga

Kazuhiro Kubo

Keiko Ochiai

Takao Iida

Mitsunobu Hara

Hiroki Ishiguro

Hidemasa Kondo

Junichi Ikeda

Hiroyuki Nagata

Toshiaki Iwazaki

Fumito Koizumi

Tsuyoshi Mokudai

Yumiko Aotani

Torataro Kobayashi

Jutaro Kobayashi

Mika Nozawa

Shinichiro Toki

Tetsuya Matsuno

Kanjiro Kobayashi

Masayuki Mochizuki

Endothelin-antagonizing peptide

There is disclosed a heat resistant cloth for fire fighting. At least an inner surface of a fluororesin film is subjected to plasma discharge treatment to form a treated surface. A vacuum-deposition film made of a bright metal such as aluminum is formed on the treated surface of the fluororesin film without use of a primer. The vacuum-deposition film on the treated surface is bonded to an outer surface of a substrate fabric through use of a silicone rubber adhesive in order to form a heat-reflecting layer on the outer surface of the substrate fabric. Since no primer coating layer is used, the heat reflecting layer can prevent a decrease in brightness, which would otherwise occur due to cracks generated in the primer coating layer. Thus, a decrease in heat reflectivity at high temperature is prevented. Since no flammable synthetic resin layer is used at the surface of the heat reflecting layer, flame resistance can be improved.

Heat resistant cloth for fire fighting

The invention relates to biologically pure cultures of Streptomyces sp. RE-701 (FERM BP-3624) and Streptomyces sp. RE-629 (FERM BP-4126) that produce endothelin antagonistic peptides.

Strains of streptomyces producing endothelin antagonistic peptides

The present invention relates to compound LK6-A represented by the formula: ##STR1## which has immunosuppressive activity, and pharmaceutically acceptable salts thereof.

Compound LK6-A

The present invention relates to EI-1941 compounds having interleukin-1 production inhibitory activity which are represented by the formula: ##STR1## wherein either of R.sup.1 and R.sup.2 is hydrogen and the other is hydroxy, or R.sup.1 and R.sup.2 together represent oxygen; and R.sup.3 is hydroxy and R.sup.4 is hydrogen, or R.sup.3 and R.sup.4 together represent --0--.

Physiologically active EI-1941 compounds

Peptides represented by the following formula (I): ##STR1## wherein A represents Asn or Asp; B represents His or Lys; and E represents Ala or Ser;

A novel physiologically active substance is represented by the formula. ##STR1## The substance is preferably derived from propolis, has excellent antitumor activity and is useful as an antitumor drug.

Physiologically active substance

Disclosed is UCA1064-B, a compound represented by formula (I): ##STR1## and having an antibacterial, antifungal and anti-tumor activity. UCA1064-B is produced by culturing a microorganism belonging to the genus Wallemia.

Compound UCA1064-B

A compound of formula (I): ##STR1## wherein R.sub.1 represents hydrogen, hydroxy or acetoxy and R.sub.2 represents hydroxy or acetoxy.

Bioxanthracene derivatives

Disclosed are DC115A compounds represented by the following general formula: ##STR1## wherein R represents ethyl, propyl or 1-propenyl, and which have antibacterial and anti-tumor activity. DC115A compounds are produced by culturing a microorganism belonging to the genus Streptomyces.

DC115A compounds produced by streptomyces sp.

UCN-1028A and UCN-1028C having an anti-tumor activity and a protein kinase C inhibitory activity are produced by culturing a microorganism belonging to the genus Cladosporium.

UCN-1028A and UCN-1028C and process for the production thereof

Growing community of inventors

Sagamihara, Japan

Mayumi Yoshida