Fujimoto Co., Ltd.

Fujimoto Brothers Co., Ltd.

Mayumi Watanabe

Fumio Yoneda

Takuya Yasusa

Takashi Ando

Hironori Ohde

Kazunori Urabe

Naoya Hoshino

Yuko Uegaki

Kenya Matsushita

Daiki Kanaoka

Yasuhiko Mizutani

Takafumi Ishii

Ikuko Tochikawa

Hironori Yokoyama

Yasuyuki Ueda

Jun Takahashi

Mitsuo Yamada

Shizuko Muraoka

Takahiro Kamada

Mikiyo Sugimoto

Azusa Takase

Mizue Hukumoto

The present invention relates to thiophene derivatives represented by the following formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof, which has TNF-&#x3b1; production suppressive activity and hematologic cancer cell proliferation inhibitory activity, and is useful for the treatment of rheumatoid arthritis, Crohn's disease, ulcerative colitis, and further, hematologic cancer.

Thiophene derivative and use thereof

There are provided a process for preparing an optically active aminopentane derivative that is promising as a psychotropic agent, an antidepressant agent, an antiparkinsonian agent, an anti-Alzheimer's agent, an apoptosis inhibitor, or the like; a novel optically active intermediate oxathiazolidine derivative very useful in the production of the aminopentane derivative; and process for the production thereof. The optically active aminopentane derivatives can be produced in an industrially advantageous manner from a novel optically active oxathiazolidine derivative represented by formula (5): wherein * indicates the position of an asymmetric carbon atom in the R or S configuration, and n is 0 or 1.

Process for preparing optically active aminopentane derivative, intermediate and process for preparing intermediate

Therapeutic agents for diabetes

2-(N-cyanoimino)thiazolidin-4-one derivatives

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Matsubara, Japan

Mayumi Watanabe