Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kirin Co., Limited

Mayumi Saki

Fumio Suzuki

Junichi Shimada

Shunji Ichikawa

Michio Ichimura

Hiromi Nonaka

Takeshi Kuboyama

Hitoshi Arai

Haruhiko Manabe

Nobuo Kosaka

Kyoichiro Iida

Hiroshi Tsumuki

Nobumasa Otsubo

Naoko Hiura

Hidenori Takada

Jun Saito

The present invention provides a preventive and/or therapeutic agent for neutrophilic inflammatory diseases which comprises, as an active ingredient, a bicyclic heterocyclic compound represented by formula (I): [wherein Rrepresents a hydrogen atom, substituted or unsubstituted alkyl, or the like, A-A-A-Arepresents N&#x2550;CR&#x2014;CR&#x2550;CR(wherein R, R, and Rare the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like), Q represents substituted or unsubstituted phenylene, and the like, and T represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aroyl, and the like].

Preventive and/or therapeutic agent for neutrophilic inflammatory diseases

The present invention provides condensed purine derivatives or pharmacologically acceptable salts thereof exhibiting adenosine A,acceptor antagonising activity, and having an antiasthmatic action, a bronchodilator action, an antiantiitching action, etc., and represented by the following formula (I):

Condensed purine derivatives

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Numazu, Japan

Mayumi Saki