Kyowa Hakko Kogyo Co., Ltd.

Mayumi Miyata

Chikara Murakata

Shiro Akinaga

Nobuyoshi Amishiro

Yoji Ino

Yukimasa Shiotsu

Shiro Soga

Harumi Ogawa

Tadakazu Akiyama

Takeshi Takahashi

Tsutomu Agatsuma

Kozue Muramatsu

Provided is steroid sulfatase inhibitors comprising, as the active ingredient, an estra-1,3,5(10)-triene derivative which is represented by formula (I):{wherein Rand Rare the same or different and represent a hydrogen atom, a lower alkyl group or, etc.; Rrepresents a hydrogen atom etc.; Rrepresents a hydrogen atom etc.; Rrepresents a hydrogen atom etc.; Rrepresents a cyano group, an amino group, COR(wherein Rrepresents a substituted lower alkyl group etc.), a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclic group, etc}, or pharmaceutically acceptable salts thereof.

Estra-1,3,5(10)-triene derivatives

Radicicol derivatives

Radioicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof:

Radicicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof:

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Chiyoda-ku, Japan

Mayumi Miyata