Osaka University

Stemrim Inc.

Genomix Co., Ltd.

Mayumi Endo

Katsuto Tamai

Takehiko Yamazaki

Natsumi Hamabuchi

Kana Naito

Tsutomu Kanezaki

Shigeru Sakurai

Yukiko Noguchi

Yasufumi Kaneda

Takenao Chino

Kotaro Saga

It was revealed that the intravenous administration of HMGB-1 and S100A8 promoted the healing of skin ulcer by recruiting bone marrow-derived cells to the site of skin ulcer. Furthermore, when HMGB-1 was intravenously administered to cerebral infarction model mice after creation of cerebral infarction, bone marrow-derived cells expressing nerve cell markers were detected in their brain. A marked cerebral infarct-reducing effect was observed in mice intravenously administered with HMGB-1 as compared to the control. The post-cerebral infarction survival rate was increased in the intravenous HMGB-1 administration group. The involvement of bone marrow pluripotent stem cells in the process of bone fracture healing was assessed using mice, and the result demonstrated that bone marrow-derived cells distant from the damaged site migrated to the bone fracture site to repair the damaged tissue.

Agents for promoting tissue regeneration by recruiting bone marrow mesenchymal stem cells and/or pluripotent stem cells into blood

(Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFR&#x3b1;-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. (Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFR&#x3b1;-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFR&#x3b1;-positive cells.

Peptide for inducing regeneration of tissue and use thereof

Growing community of inventors

Osaka, Japan

Mayumi Endo