Canon Kabushiki Kaisha

Mayuko Kishi

Satoshi Yuasa

Kengo Kanazaki

Tetsuya Yano

Tatsuki Fukui

Masato Minami

Yasuhiko Tabata

Satoshi Ogawa

Fumio Yamauchi

Daisuke Sasaguri

Sachiko Yamauchi

Fumiko Tomatsu

Mika Yamagata

An iron oxide particle constituting a Resovist (trademark) absorbs a small quantity of light in a near infrared region and emits a weak photoacoustic signal. According to a particle having a catechol-like compound and iron atoms, the particle having a ratio of the number of moles of the catechol-like compound to the number of moles of the iron atoms of 270/10,000 or more, light absorption in the near infrared region increases and a strong photoacoustic signal can be transmitted.

Particle and photoacoustic contrast agent having the particle

Provided is a particle which can stably hold a dye in itself even in an aqueous solution such as serum, in order to solve such a problem of a particle containing ICG, which has been conventionally used in a contrast agent or the like, that the ICG is a dye having a hydrophilic functional group and hence the ICG leaks out of the particle in an aqueous solution such as serum. More specifically, provided is a particle including a hydrophobic dye having a cyanine structure, in which the hydrophobic dye is represented by the following chemical formula (1). 

Particle containing hydrophobic dye having cyanine structure, and contrast agent containing the particle

A compound including a polymer is represented by general formula (1):L-Y-A&#x2003;&#x2003;(1)wherein, A is a single-chain antibody moiety, which is a polypeptide including an antigen-binding site, L is a linker moiety, which is a polypeptide including a protease cleavage site, Y is a peptide moiety, which includes 0 or more amino acids connecting the linker moiety L with the single-chain antibody moiety A, and the linker moiety L binds to an N terminus of the peptide moiety Y or an N terminus of the single-chain antibody moiety A.

Compound

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Machida, Japan

Mayuko Kishi