Trimeris, Inc.

Maynard Lichty

Brian L Bray

Myung-Chol Kang

Catherine Mader

Brian Bray

Gene Merutka

The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as &ldquo;DP-178&rdquo;; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides of interest (e.g., T-20). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full length T-20 and T-20-like peptides.

Methods and compositions for peptide synthesis

The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as 'DP-178'; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides of interest (e.g., T-20). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full length T-20 and T-20-like peptides.

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Durham, NC, United States of America

Maynard Lichty