Glaxo Group Limited

Besins Healthcare Luxembourg Sarl

Maynard Emanuel Lichty

John Joseph Partridge

Garry Thomas Gwozdz

Brian L Bray

John P Turnbull

Provided herein are dry pharmaceutical compositions for transmucosal delivery, comprising spray-dried particles that include pharmaceutically active agent nanoparticles, a binder, and a pharmaceutically acceptable carrier, where the active agent nanoparticles have an average particle size diameter prior to spray-drying of less than about 1 &#x3bc;m, and wherein up to 10% of the spray-dried particles have a particle size of less than 10 &#x3bc;m; at least 50% of the spray-dried particles have a particle size of at least about 15 &#x3bc;m; and at least 90% of the spray-dried particles have a particle size of up to about 55 &#x3bc;m. Also provided are methods for making such pharmaceutical compositions and therapeutic methods comprising transmucosally aministering the compositions, such as intranasally or intravaginally.

Spray-dried pharmaceutical compositions comprising active agent nanoparticles

Provided herein are dry pharmaceutical compositions for transmucosal delivery, comprising spray-dried particles that include pharmaceutically active agent nanoparticles, a binder, and a pharmaceutically acceptable carrier, where the active agent nanoparticles have an average particle size diameter prior to spray-drying of less than about 1 &#x3bc;m, and wherein up to 10% of the spray-dried particles have a particle size of less than 10 &#x3bc;m; at least 50% of the spray-dried particles have a particle size of at least about 15 &#x3bc;m; and at least 90% of the spray-dried particles have a particle size of up to about 55 &#x3bc;m. Also provided are methods for making such pharmaceutical compositions and therapeutic methods comprising transmucosally administering the compositions, such as intranasally or intravaginally.

A process for removing osmium from an aqueous solution of nucleosides comprising adding hydrogen sulfide, an aromatic pi base such as pyridine, and a mineral acid. The osmium is precipitated out of solution.

Method for removing osmium from nucleosides

Synthesis of the triol of formula (I) or its amine-protected derivative from a cyclopentene of the formula (II) or its amine-protected derivative: ##STR1## via steps including oxidation to the aldehyde, migration of the double bond, reduction of the aldehyde moiety back to the alcohol grouping and 1,2-cis-dihydroxylation of the double bond.

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Durham, NC, United States of America

Maynard Emanuel Lichty