Abbvie Inc.

Mayda Perez Thiele

Christopher Chumsae

Xiaobei Zeng

Kartik Subramanian

Chee Furng Wong

Zehra Kaymakcalan

Ying Jing

The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations.

Methods to modulate lysine variant distribution

The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF&#x3b1; is detrimental, are also provided.

Modulated lysine variant species compositions and methods for producing and using the same

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Vega Alta, Puerto Rico

Mayda Perez Thiele