Ramot at Tel-aviv University Ltd.

Allon Therapeutics, Inc.

Maya Maor

Illana Gozes

Saar Oz

Inna Divinski

David Dangoor

Alistair Stewart

Sharon Furman-Assaf

The invention is based on the discovery of a novel neuroprotective peptide. In addition, the invention rests on the discovery that the NAP peptide enhances the association of tau and the brain-specific beta tubulin subunit. In addition, NAP modifies microtubule assembly and dynamics, in part, by affecting the tyrosination of microtubule proteins. The invention provides compositions and methods for treatment and prevention of neuronal disorders, including NAP-binding and tau-binding agents, tau peptide mimetics, NAP-like and NAP-like tau peptide mimetics.

Therapeutics based on tau/microtubule dynamics

This invention relates to NAP-like and SAL-like peptide mimetics, polypeptides, or small molecules derived from them, and their use in the treatment of neuronal dysfunction, neurodegenerative disorders cognitive deficits, neuropsychiatric disorders, and autoimmune disease.

Neuroprotection using NAP-like and SAL-like peptide mimetics

Growing community of inventors

Petach-Tikva, Israel

Maya Maor