Harbor Branch Oceanographic Institution, Inc.

May S Lui

Sarath P Gunasekera

Yoel Kashman

Tatsuo Higa

Ryuichi Sakai

Kenneth L Rinehart

Amy E Wright

Peter J McCarthy

Sue S Cross

Neal S Burres

Winnie C Thompson

H Howard Sun

Shinichi Sakemi

Shigeo Kohmoto

Shinji Tsujii

Novel brominated bisindole-imidazole alkaloids have been isolated from marine sponges. These compounds, and derivatives thereof, are useful antimicrobial and antitumor compounds.

Bis-indole imidazole compounds which are useful antitumor and

This invention relates to novel polyacetylene compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor polyacetylenes which are derived form marine organisms, i.e., the marine sponge Cribrochalina dura.

Novel polyacetylene compositions and their methods of use

This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine organisms, i.e., the marine sponge Amphimedon sp.

Antitumor alkaloids

A new class of novel, biologically active bisindole alkaloid compounds, which have been named topsentins, pharmaceutical compositions containing them, methods of producing the compounds and methods of using them are disclosed. This new class of compounds has the generic formula: ##STR1## R.sup.1-8 are the same or different selected from --H, --OH, halogen, --R, --OR, --OCOR, or --OA;

Topsentin compounds effective against viruses and certain tumors

This invention relates to novel macrolide compositions which are useful as antitumor, antiviral and antifungal compositions, a process of producing the compositions and a method for inhibiting tumors, viruses and fungi utilizing the compositions. More particularly, the novel macrolide compositions are organic misakinolide and misakinolide derivative compositions which are derived from marine sponges genus Theonella.

Misakinolide compositions and their derivatives

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Vero Beach, FL, United States of America

May S Lui