University of Washington

General Electric Company

Global Life Sciences Solutions Operations UK Ltd

Maxwell Wheeler

Lisa Kathryn Lafleur

Joshua Davis Bishop

David Roger Moore

Matthew Jeremiah Misner

Andrew Arthur Paul Burns

Paul Yager

Barry R Lutz

Elain S Fu

Samantha A Byrnes

Peter C Kauffman

Sujatha Kumar

Jared Houghtaling

Tinny Liang

Joshua Buser

Bhushan Toley

Shivani Dharmaraja

Xiaohong Zhang

The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

Amplification and detection of nucleic acids

The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a porous receiving element having an input region and a receiving region, a first fluid source and a second fluid source positioned within the input region of the receiving element; wherein the first fluid source is positioned between the second fluid source and the receiving region, and wherein, when both the first and second fluid sources are in fluid connection with the input region, the device is configured to sequentially deliver the first fluid and the second fluid to the receiving region without leakage.

Sequential delivery of fluid volumes and associated devices, systems and methods

Growing community of inventors

Seattle, WA, United States of America

Maxwell Wheeler