Human Genome Sciences, Inc.

Other

Smithkline Beecham Corporation

Maxine Gowan

Mark D Adams

Claire M Fraser

Ewen F Kirkness

Gregg A Hastings

Lisa M Fitzgerald

Fred H Drake

Judith A Blake

Norman H Lee

Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.

Human osteoclast derived cathepsin

Human osteoclast-derived cathepsin

Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases. A patient is treated by administering an antibody produced against a polypeptide consisting of SEQ ID NO: 2.

Treatment of a patient by administering an antibody that inhibits cathepsin O

Growing community of inventors

Valley Forge, PA, United States of America

Maxine Gowan