Hoffmann-la Roche Inc.

Roche Glycart Ag

F. Hoffmann-la Roche Ag

Maximiliane Koenig

Ekkehard Moessner

Christian Klein

Pablo Umana

Guy Georges

Wolfgang Schaefer

Stefan Seeber

Joerg Thomas Regula

Thomas U Hofer

Laurent Lariviere

Ralf Hosse

Peter Bruenker

Tilman Schlothauer

Sabine Imhof-Jung

Jens Niewoehner

Joerg Moelleken

Tina Weinzierl

Claudia Ferrara Koller

Sandra Grau-Richards

Huisheng Wang

Kathryn Elizabeth Packman

Inja Waldhauer

Barbara Weiser

Valeria Runza

Huifeng Niu

Sherif Daouti

Ningping Feng

Hubert Kettenberger

Michael Molhoj

Jens Fischer

Johannes Auer

Martin Bader

Stefan Lorenz

Vincent Larraillet

Katja Montan

Bianca Gruenwalder

Kasper Rand

Pernille Foged Jensen

The present invention generally relates to antibodies that bind to STEAP-1, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

Antibodies binding to STEAP-1

Use of a limited digestion with a proteolytic enzyme of a multispecific antibody for the analysis of the multispecific antibody's light chain pairing.

Method for detecting multispecific antibody light chain mispairing

The present invention relates to bispecific antibodies comprising at least one antigen binding site specific for DR5 and at least one antigen binding site specific for FAP, antibodies specific for DR5, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

Antibodies specific for DR5 and methods of use

Bispecific antibodies specific for FAP and DR5, antibodies specific for DR5

The present invention relates to Bispecific antibodies against human TWEAK and human IL17 (bispecific TWEAK-IL17 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

Bispecific antibodies against human TWEAK and human IL17 and uses thereof

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Pullach, Germany

Maximiliane Koenig