Sandoz Gmbh

Novartis Ag

Novarits Ag

Novartis Pharma Gmbh

Meda Pharma Sarl

Maximilian Grassberger

Peter Stutz

Josef Gottfried Meingassner

Anton Stutz

Amarylla Horvath

Hans Tscherter

Gerhard Penn

Dierk Wieckhusen

Michael Morris Dreyfuss

Sabine Pfeffer

Jean-Paul Mutz

Gerhard Emmer

Gabor Petranyi

Otto Hartmann

Andrew J Edmunds

Cornelia Dosenbach

Klaus Ruedi

A process for the production of 33-Epi-33-chloro-FR 520 in one step from FR520 wherein protecting groups are avoided.

Heteroatoms-containing tricyclic compounds

Crystalline macrolides and process for their preparation

The compounds of formula I, ##STR1## have been found to have excellent topical activity. They are thus indicated for use in the topical treatment of inflammatory and hyperpoliferative skin diseases and of cutaneous manifestations of immunologically-induced illnesses, such as psoriasis.

Use of 11,28-dioxa-4-azatricyclo[22.3.1.0.sup.4,9 ]octacos-18-ene

Pipecolic acid-containing peptolides wherein the peptidic backbone is of at least 9 .alpha.-amino acid residues joined together by peptide bonds, particularly the compounds of formula I ##STR1## wherein the substituents have various significances, are disclosed. They can be prepared by isolation or derivation from an appropriate microorganism strain such as S 42508/F (NRRL 15761). They have interesting pharmacological, e.g. antifungal, chemotherapeutic drug resistance reversing and to some extent immunosuppressant and antiinflammatory properties.

Pipecolic acid-containing peptolides, their preparation and

New use of 11,28-dioxa-4-azatricyclo[22.3.1.0.sup.4,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing them The compounds of formula I, ##STR1## have been found to have excellent topical activity. They are thus indicated for use in the topical treatment of inflammatory and hyperpoliferative skin diseases and of cutaneous manifestations of immunologically-induced illnesses, such as psoriasis.

The compounds of formula I ##STR1## wherein the substituents have various significances, possess pharmacological, particularly antiinflammatory and immunosuppressant activity. They can be prepared by one or more of the following process variants: reduction, deprotection, acylation, reaction with N,N'-carbonyl- or N,N'-thiocarbonyldiimidazole, halogenation, splitting off of hydrogen halide, reaction with a hydrogen carbonate, radical deoxygenation, dehydration or reaction with diazomethane of -ethane, optionally under transient protection of reactive groups which it is not desired to react.

Benzopyrane and benzothiopyrane derivatives which possess pharmaceutical in particular anti-mycotic activity.

Benzopyrane and benzothiopyrane derivatives useful as anti-mycotic agents

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Vienna, Austria

Maximilian Grassberger