Labopharm Inc.

Thallion Pharmaceuticals Inc.

Labopharm Europe Limited

Labopharm (barbados) Limited

Paladin Labs Inc.

Paladin Labs Europe Limited

Maxime Ranger

Jean-christophe Leroux

Jean-Christophe Leroux

David Lessard

Sandra Gori

Laibin Luo

Frederic Lebrun

Lu Wei Liu

Genevieve Bibeau

Jean-Francois Meunier

Julie Lafreniere

Yuan Wang

James B McAlpine

François Berger

Henriette Gourdeau

Arjun H Banskota

Mustapha Aouidate

Faustinus Yeboah

Bryan Simard

Ashraf Ibrahim

Gregory L White

Geneviève Bibeau

Jean-François Meunier

The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.

Process for the preparation of amphiphilic poly(N-vinyl-2-pyrrolidone) block copolymers

This invention relates to methods of inhibiting growth and/or proliferation of a neoplastic cell, and methods of treating neoplasms by administration of the farnesylated dibenzodiazepinone compound of Formula I via continuous intravenous infusion. The invention includes pharmaceutical compositions comprising the compound of Formula I: 

Methods for administration of a farnesyl dibenzodiazepinone

The present invention is directed toward water-soluble supramolecular self-assemblies and a process for their preparation via micellization of polyelectrolytes through the use of hydrophobic monomeric units. In this invention the polyelectrolyte segment ultimately forms the core of the supramolecular assembly whereas the shell consists of uncharged hydrophilic polymers or oligomers. It has been determined that the inclusion of the hydrophobic co-monomers to the polyelectrolyte segment forming the micelle core leads to a structure of enhanced stability.

Water-soluble stabilized self-assembled polyelectrolytes

This invention relates to phosphate prodrugs of a farnesylated dibenzodiazepinone, to processes of their manufacture, to pharmaceutical compositions comprising the prodrugs, and to their use in the treatment of neoplasms.

Phosphate prodrugs of a farnesyl dibenzodiazepinone, processes for their production and their use as pharmaceuticals

Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers

The present invention describes the preparation of unimolecular polymeric micelles (UPM) that bear a hydrophilic shell and a potentially ionizable and relatively hydrophobic core at a determined pH value. The core becomes electrostatically charged as the pH is changed. Such micelles can be made from either biodegradable or non-biodegradable polymers. Loaded drugs can be physically retained in the micelles when the pH of the surrounding medium favors interactions with the core. Upon a change in pH, modification in the ionization state of the core will decrease the interactions between the drug and the inner core and facilitate the release of the micellar contents.

Unimolecular polymeric micelles with an ionizable inner core

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Montreal, Canada

Maxime Ranger