Centre National De La Recherche Scientifique

Universitë De Bordeaux

Institut D'optique Theorique Et Appliquee

Institut D'obtique Théorique Et Appliquée

Treefrog Therapeutics

Maxime Feyeux

Pierre Nassoy

Laurent Cognet

Kevin Alessandri

Erwan Bezard

Abdelhamid Benazzouz

Gaëlle Recher

Kevin Allessandri

The invention relates to a neural tissue unit for use in implantation into the nervous system of a human or non-human mammal, wherein said neural tissue unit contains differentiated post-mitotic neuronal cells in an extracellular matrix, said unit being obtained from a cellular microcompartment comprising a hydrogel capsule surrounding the neural tissue unit, and said hydrogel capsule being at least partially removed before use of the neural tissue unit. The invention also relates to a process for preparing such a neural tissue unit.

Neural tissue unit and use of such a unit for implantation into the nervous system of a mammal

The invention relates to a cellular microcompartment comprising successively, organized around a lumen, at least one layer of pluripotent cells, an extracellular matrix layer and an outer hydrogel layer. The invention also relates to processes for preparing such cellular microcompartments.

Cellular microcompartment and preparation processes

The invention relates to a process for producing a plurality of capsules, each comprising an external shell of crosslinked hydrogel surrounding a central core, according to which a hydrogel solution and a composition of interest, intended to form the central core, are concentrically co-extruded so as to form mixed drops, each comprising a layer of hydrogel solution surrounding a drop of liquid composition of interest, characterized in that the co-extrusion step is carried out above a crosslinking aerosol so that the mixed drops pass through said crosslinking aerosol, such that the layer of hydrogel solution at least partially crosslinks around the drop of liquid composition of interest on contact with said aerosol.

Process for producing capsules made of an external shell of crosslinked hydrogel surrounding a central core

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Talence, France

Maxime Feyeux