Centre National De La Recherche Scientifique

Atlanthera

Institut National De La Sante Et De La Recherche Medicale

Université De Nantes

Chu Nantes

Maxim Egorov

Joanna Bakala

Jérôme Bignon

Jean-Yves Goujon

Ronan Le Bot

Dominique Heymann

Jacques Lebreton

Maria Conception Achab

Bernard Delpech

Monique Mathé

Pascal Collin

Francoise Redini

Jérome Bignon

Odile Thoison

Michel Benechie

Emmanuelle David

Yannick Fortun

Marc Padrines

Monique Mathe

Maria Achab

Françoise Redini

The invention relates to hydrosoluble hydroxybisphosphonic derivatives of doxorubicin of formula (I) and the pharmaceutically acceptable salts thereof. The invention also relates to the use of said compounds as a drug, especially in the treatment of a bone tumour. The invention further relates to the pharmaceutical compositions comprising such compounds, the methods for the synthesis thereof and synthesis intermediates. 

Hydrosoluble hydroxybisphosphonic derivatives of doxorubicin

The present invention relates to a compound of formula (I) in which: -m is an integer from 0 to 3, preferably from 0 to 2; n is an integer from 0 to 3, preferably from 0 to 2; m+n&#x2267;1; EAG is an electro-attractive group chosen independently from among a halogen atom, an NO, CF, CCI, CN, COH, (C&#x2550;O)NR, CH&#x2550;NR, (C&#x2550;S)OR, (C&#x2550;O)SR, CSR, SOR, SONR, SOR, P(O)(OR), P(O)(R), B(OR)group where R is a (C-C) alkyl radical, a phenyl group or a hydrogen atom; A is a saturated or unsaturated, linear or branched hydrocarbon chain including 1 to 10 atoms of carbon; and Rand Reach represent independently from one another a hydrogen atom, a CO-(Ci-C6)-alkyl, (C-C) alkyl, phenyl or phenyl-(C-C)-alkyl group, in which Rand Rform, together with the nitrogen atom they carry, a 5- to 15-member heterocycle, optionally substituted by a (C-C) alkyl group; including its stereoisomers and the mixtures thereof, or a pharmaceutically acceptable salt of same. 

N-substituted 3,4-bis (catechol) pyrrole compounds, and the preparation and use thereof in the treatment of cancer

The present invention relates to a bifunctional hydroxy-bisphosphonic acid derivative of formula (I) below: or a pharmaceutically-acceptable salt thereof,a method for producing the same, pharmaceutical compositions containing the same,and the use thereof as a medicament,as well as a compound of formula (II) below: or a pharmaceutically-acceptable salt thereof,and the use thereof for producing a vectorized molecule of therapeutic or diagnostic purpose.

Bifunctional hydroxy-bisphosphonic acid derivatives

The present invention relates to hydroxy-bisphosphonic acid derivatives corresponding to general formula (I): in which: -n and m denote, independently of one another, an integer ranging from 1 to 4, &#x2014;X denotes an oxygen atom or an N&#x2014;R3 group, &#x2014;R1 and R3 denote, independently of one another, a linear or branched Cto Calkyl group, and &#x2014;R2 denotes a residue of a molecule of therapeutic or diagnostic interest, or pharmaceutically acceptable salts of said derivatives, and also the method for the preparation thereof and the therapeutic or diagnostic use thereof. 

Hydroxy-bisphosphonic acid derivatives as vector targeting bone tissue

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Bouguenais, France

Maxim Egorov