The University of British Columbia

Max S Cynader

Guang Yang

Francis Tufaro

Pierre Zakarauskas

Isolated polypeptides are disclosed herein, the isolated polypeptides comprising at least 90% identity to any one of: SEQ ID NO:1; SEQ ID NO:2; or SEQ ID NO:3, wherein the isolated polypeptide inhibits an interaction between palmitoyl acyl transferase zinc-finger DHHC type containing 17 (z D17) and c-jun N-terminal kinase (JNK). The polypeptides may be conjugated to a delivery and targeting moiety, such as the cell-membrane transduction domain of the HIV-1 Tat protein. There are also provided methods for treating a disease associated with cytotoxicity or excitotoxicity.

Neuroprotective peptides that inhibit interaction between palmitoyl acyl transferase zinc-finger DHHC type containing 17 (zD17) and c-jun N-terminal kinase (JNK)

Methods for treatment, processes for preparing, and compositions for delivering selected nucleic acid sequences to cells, primarily of the treatment of neurological disorders and exploring neurological functions, are disclosed. In particular, the invention provides recombinant Herpesvirus vectors with a high rate of expression of selected nucleic acid sequences and/or a low cytopathicity and its associated methods and processes.

Method of using, process of preparing and composition comprising

A self-steering platform system incorporates at least three and preferably four microphones circumferentially spaced about the platform which is mounted for movement preferably around two mutually perpendicular axes. A sound source is selected and separate audio signals from the microphones are analyzed by a control which based on differences between the signals from the microphones emanating from the selected source determines the location of the selected source. The orientation of the platform is then adjusted by the control relative to the selected sound source. The present invention is particularly useful for mounting a shotgun or parabolic microphone to enhance sound from a selected source.

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Vancouver, Canada

Max S Cynader