Mallinckrodt Medical, Inc.

Max D Adams

James F Godat

Raghavan Rajagopalan

Dennis A Moore

David H White

Muthunadar P Periasamy

Steven R Woulfe

William P Cacheris

Lynn A deLearie

A delivery apparatus in the form of a syringe assembly and piston with structure for preventing withdrawal of the piston a distance more than the thickness of one piston. The syringe is preferably prefilled and sterilized to provide a sterile syringe assembly with sterile fluid contents. Controlled, limited withdrawal of the piston facilitates aspiration of the syringe without the contamination risks caused by withdrawing the piston so as to allow the sterile fluid to contact the exposed portion of the syringe container portion behind the piston.

Insert device for facilitating limited aspiration of a delivery apparatus

Methods and compositions are disclosed for enhancing .sup.19 F magnetic resonance imaging which utilize .sup.19 F magnetic resonance contrast media having enhanced .sup.19 F relaxivity. Fluorine-containing compounds having enhanced .sup.19 F relaxation properties resulting from direct association with an unpaired spin are disclosed. The fluorine-containing compound is associated with the unpaired spin by covalent attachment of a stable free radical, by complexation of a fluorinated complexing agent with a paramagnetic metal ion, or by salt formation or charge neutralization of a paramagnetic ion.

19F magnetic resonance imaging agents which include a nitroxide moiety

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St. Charles, MO, United States of America

Max D Adams