Pfizer Corporation

Mavis Diane Adam

Harry Ralph Howard

David Hepworth

Donald Stuart Middleton

Alan Stobie

Harry R Howard, Jr

Geoffrey E Gymer

Mark David Andrews

Mark Leonard Elliott

The invention relates to compounds of formula I 

Phenyl heterocyclyl ethers

A compound of general formula (I) wherein R and R are H, C -C alkyl or (CH ) (C -C cycloalkyl) wherein d&equals;0, 1, 2 or 3; or R and R together with the nitrogen to which they are attached form an azetidine ring; Z or Y is &mdash;SR and the other Z or Y is halogen or &mdash;R ; wherein R is C -C alkyl optionally substituted with fluorine; except that R is not CF ; or Z and Y are linked so that, together with the interconnecting atoms, Z and Y form a fused 5 to 7-membered carbocyclic or heterocyclic ring, and wherein when Z and Y form a heterocyclic ring, in addition to carbon atoms, the linkage contains one or two heteroatoms independently selected from oxygen, sulfur and nitrogen; R and R , which may be the same or different, are: A&mdash;X, wherein A&equals;&mdash;CH&boxH;CH&mdash; or &mdash;(CH ) &mdash; where p is 0, 1 or 2; X is hydrogen, F, Cl, Br, I, CONR R , SO NR R , SO NHC(&boxH;O)R , OH, C alkoxy, NR SO R , NO , NR R , CN, CO R , CHO, SR , S(O)R or SO R ; or a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O, optionally substituted independently by one or more R ; wherein R is hydroxy, C -C alkoxy, F, C -C alkyl, haloalkyl, haloalkoxy, &mdash;NH , &mdash;NH(C -C alkyl) or &mdash;N(C -C alkyl) .

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Niantic, CT, United States of America

Mavis Diane Adam