Firmenich Sa

Bayer Pharma Aktiengesellschaft

Dsm IP Assets B.v.

Maurus Marty

Christian Chapuis

Anthony Alexander Birkbeck

Franz-Josef Mais

Christian Vial

Heiko Schirmer

Andreas Lender

Kai Lovis

Philipp Rubenbauer

Jan Schuetz

Juergen Stiehl

Danja Grossbach

Hervé Mosimann

Jan-Georg Peters

Eric Walther

Roman Goy

Martin Seyfried

Theodor Zweifel

Günter Weingärtner

Ralph Waechter

Jean-François Basset

Daniel Götz

Danja Großbach

Harvey Randall

Simon Linder

Daniel Gotz

Gunter Weingartner

Claude Alban Furer

Julia Witte

The present invention relates to a novel method of preparing copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride. The present invention also relates to copanlisib dihydrochloride hydrates as compounds.

Synthesis of copanlisib and its dihydrochloride salt

The present invention relates to the field of perfumery and concerns the use as perfuming ingredient of ketones of formula wherein n represents 0, 1 or 2, m represents 0, 1 or 2, the dotted lines represent only single bonds or one double bond and two single bonds, Rrepresents a hydrogen atom or a methyl or ethyl group, said Rgroup being located at any of the position of the cyclic moiety, Rrepresents a C-CO-alkyl or O-alkenyl group or a substituted or unsubstituted ethylene or cyclopropyl group. Said compounds are useful to impart a clean and natural fruity, pineapple odor type. The present invention concerns also the compositions or articles containing said compounds (I) as well as some of said compounds (I). 

Ketones as perfuming ingredients

A method to confer, enhance, improve or modify the odor properties of a perfuming composition or of a perfumed article by adding to the composition or article an effective amount of at least one compound of formula I: wherein n represents 0, 1 or 2; m represents 0, 1 or 2; the dotted lines represent only single bonds or one double bond and two single bonds; Rrepresents a hydrogen atom or a methyl or ethyl group, and Rrepresents an ORgroup, Rrepresenting a C-Calkyl or alkenyl group; a group of formula CR&#x2550;C(R), or a group of formula with Rrepresenting a hydrogen atom or a methyl or ethyl group. These compounds impart a clean and natural fruity, pineapple odor type to the perfuming compositions or perfumed articles to which they are added.

A compound of formula wherein the symbol R' represents a linear or branched, unsaturated or saturated hydrocarbon group having from 1 to 5 carbon atoms; R, R, R, Rand Rrepresent, independently of each other, a hydrogen atom, a methyl, an ethyl or a methoxy group; Rand Rrepresent, independently of each other, a hydrogen atom, a methyl, ethyl, n-propyl or iso-propyl group; and wherein Rand R, when taken together with the carbon atoms to which they are bound, may form a six-membered ring, is useful as perfuming ingredient for the preparation of perfuming compositions and perfumed products, to which it imparts odor notes of the floral and indol type without coloring problems in the final product.

Utilization of unsaturated esters as perfuming ingredients

The present invention relates to the field of perfumery or flavor. More particularly, it concerns 3-(4,4-dimethyl-1-cyclohexen-1-yl)propanal and its use as perfuming or flavoring ingredient, as well as the compositions or articles associated with said compound.

Aldehyde as perfuming or flavoring ingredient

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Seon, Switzerland

Maurus Marty