Farmitalia Carlo Erba S.p.a.

Farmitalia Carlo Erba S.r.l.

Farmitalia Carlo Erba

Mauro Gigli

Sergio Penco

Francesco Angelucci

Roberto De Castiglione

Giuseppe Perseo

Fernando Giuliani

Barbara Hecht

Anthracycline glycosides having the general formula (A): ##STR1## wherein R.sub.1 is hydrogen, hydroxy or methoxy; R.sub.2 is amino, R.sub.3 is hydrogen or hydroxy and X is hydrogen; and their pharmaceutically acceptable salts; are antitumor agents. The compounds are obtained by reduction of the corresponding 6-nitro derivatives with stannous chloride in presence of sodium acetate or with palladium or charcoal in presence of cyclohexene.

6-amino anthracyclines, process for their preparation and use thereof

Anthracycline glycosides of the general formula (A'): ##STR1## wherein R.sub.1 represents a hydrogen atom, a hydroxy group or a methoxy group; one of R.sub.2 and R.sub.3 represents a hydroxy group and the other of R.sub.2 and R.sub.3 represents a nitro group; and R.sub.4 represents a hydrogen atom or a hydroxy group; and their pharmaceutically acceptable salts; have anti-tumor activity.

Nitro anthracyclines, process for their preparation and use thereof

There are provided peptides of the formula

Biologically active heptapeptides

Growing community of inventors

Merano, Italy

Mauro Gigli