Cerbios-pharma Sa

Hc-pharma Ag

Chemelectiva Srl

Selego Ab

Chemi S.p.a.

Mauro Gaboardi

Graziano Castaldi

Marco Baratella

Marta Castaldi

Giuseppe Pallanza

Erminio Oldani

Alessandro Baruto

Sara Helmy

Lars Fredriksson

The present invention relates to a process for the synthesis of cysteamine or a salt thereof.

Process for the preparation of a sulfur-amine

A process for the synthesis of Sofosbuvir is provided comprising the steps of selectively mono-deacetylating a compound of formula (V) enzymatically using a resin supported lipase B derived fromto obtain a compound formula (IV), then converting the compound of formula (IV) to a compound of formula (II) by reacting the compound of formula (IV) with a compound of formula (III), and then converting the compound of formula (II) to Sofosbuvir of formula (I) by deacetylation reaction.

Process for the preparation of sofosbuvir

Sofosbuvir in crystalline Form &#x3b1;, process for its production and use in pharmaceutical compositions.

Sofosbuvir in crystalline form and process for its preparation

Novel retinoic acid derivatives and a process for their preparation are described.

Retinoid derivatives and process for their preparation

A process for the preparation of Erlotinib is disclosed in which the compound of formula (II)  and the reaction product is subsequently treated with a source of hydrochloric acid in a suitable solvent to give Erlotinib hydrochloride.

Process for the preparation of erlotinib

The present invention relates to a process for the synthesis of dasatinib and to intermediates useful for its preparation.

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Novara, Italy

Mauro Gaboardi