Chemi S.p.a.

Mauro Annibaldi

Lorenzo De Ferra

Barbara Pinto

Ettore Ammirati

Simona Andreassi

Luca Mandelli

Felice Stracqualursi

The present invention relates to a process for the preparation of a polysaccharide composed of D-xylose units of formula (III) linked together via beta 1,4 glycosidic bonds wherein Ris hydrogen or acetyl, Ris hydrogen, acetyl or a 4-O-methyl glucuronic acid unit, wherein, when Ris a 4-O-methyl glucuronic acid unit, the Rgroup on the same saccharide unit is defined as G, wherein G is hydrogen or acetyl, and wherein the sugar unit at the reducing end of sun such polysaccharide is xylose, lyxose or xylulose, said process comprising the following steps: selective deacetylation of xylan extracted from beech wood; and isomerization of the selectively deacetylated xylan achieved in step or the following steps: isomerization of xylan extracted from beech wood; and selective deacetylation of isomerized xylan achieved in step. The process is useful for the preparation of pentosan polysulfate or pharmaceutically acceptable salts thereof for pharmaceutical use.

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Patrica, Italy

Mauro Annibaldi