Zach System

Zach Systems S.p.a.

F.i.s. Fabbrica Italiana Sintetici S.p.a.

Mauro Andretto

Livius Cotarca

Massimo Verzini

Raffaella Volpicelli

Antonio Nardi

Paolo Maragni

Roberto Brescello

Ivan Michieletto

Alfonso Melloni

Ilaria Munari

Elisa Melotto

Anna Smaniotto

Corrado Colli

The present invention relates to a chiral oxamide of formula (I) useful as an intermediate in the preparation of dorzolamide, and to the preparation thereof. The invention also relates to the preparation of dorzolamide, to the hydrochloride salt thereof, and to the active ingredient contained in a drug useful in the treatment of glaucoma, by means of the intermediate of formula (I). 

Process for preparing enantiomerically enriched oxamides

The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.

Process for preparing Bosentan monohydrate and it's intermediates

The present invention relates to a stereoselective reduction procedure to obtain, by means of catalytic asymmetric hydrogenation by hydrogen transfer, a compound of formula (I) in which X is S or SOand Ris hydrogen or an SONHgroup, from the corresponding ketone precursor, said compound of formula (I) being useful as an intermediate in the preparation of dorzolamide or of the hydrochloride salt thereof. 

Asymmetric reduction process

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Noventa Vicentina, Italy

Mauro Andretto