Acs Dobfar S.p.a.

Finpael S.p.a.

Pfizer Corporation

Maurizio Zenoni

Leonardo Marsili

Antonio Manca

Riccardo Monguzzi

Angelo Giovanni Cattaneo

Mario Leone

Claudio Fuganti

Giovanni Fogliato

Alessandro Donadelli

Giuseppe Alessandro Donadelli

Marco Forzatti

Juan C Colberg

Riccardo Colombo

Marco Silvagni

Mixtures of at least two active principles, of which at least one is the sodium salt, are precipitated from an organic solution containing the same active principles in salified or non-salified acid form.

Injectable sterile pharmaceutical formulation containing at least two active principles

Method for purifying 7&#x3b1;-methoxy-cephalosporins containing as impurity the corresponding 7&#x3b1;-methylthio analogue, which is transformed into its methoxy analogue by treatment with a halogenating agent in methanol. In this way the complete conversion of the sulphurated impurity into the corresponding methoxy analogue is obtained.

Purification of beta-lactam products

Crystalline acetonitrile solvate of cefuroxime acid, useful for preparing the antibiotic cefuroxime sodium salt.

Crystalline solvate of cefuroxime acid

Cefalotin is methoxylated in position 7&#x3b1;, desacetylated and then carbamoylated in position 3, to provide acid cefoxitin without any isolation of intermediate products. The acid cefoxitin is then transformed into the sodium salt by means of ion exchange resin.

Process for preparing sodium cefoxitin

The invention relates to a method for obtaining cefotetan acid substantially free of tautomer, by treating crude cefotetan with Alions which cause the tautomer to precipitate. The precipitate is eliminated by filtration to provide a solution from which practically tautomer-free cefotetan is obtained.

Process for obtaining cefotetan with high yield

Process for producing Cefepime, Cefpirome and Cefquinome, whereby a cephalosporin containing a quaternary ammonium group is reacted with thiourea to provide the aforesaid cephalosporins.

Process for producing Cefepime and cephalosporin analogues

A process for the preparation of 3-cyclic-ether-substituted cephalosporins of formula I wherein the group CORis a carboxylic acid or a carboxylate salt and Rhas the formula: wherein wherein Ris as defined above and Ris para-nitrobenzyl or allyl with a compound RL wherein Ris as defined above; and L is di-(Calkyl)phosphorothioate in the presence of a solvent and a base.

Coupling process and intermediates useful for preparing cephalosporins

Cephalosporins may be conveniently prepared by a process in which a benzathinium salt of formula (V) wherein:

Process for preparing cephalosporins with salified intermediate

A safe and economical process for obtaining salts of 4-carboxy-3-hydroxy-5-mercapto-isothiazole. This process comprises refluxing a disodium or dipotassium salt of 3-hydroxy-5-mercapto-4-isothiazole carbonitrile in an aqueous solution of sodium or potassium hydroxide to produce the desired salt. The desired salt may be precipitated out of solution by adjusting the pH downward to a minimum value of about pH 8. Compounds produced by this process may be used for producing semi-synthetic cephalosporins.

Process for obtaining compounds usable in the production of Cefotetan, and new compounds obtained thereby

A bioavailable crystalline form of cefuroxime axetil, obtained by treating known crystalline or amorphous cefuroxime axetil with water or with a water-miscible organic solvent or with a mixture thereof at a temperature of between +20.degree. C. and +100.degree. C., followed by cooling and separating the crystalline product by known methods.

Bioavailable crystalline form of cefuroxime axetil

Process for selectively reducing cephalosporin sulfoxides of 3-hydroxy cephem and 3-methylene cepham compounds by treatment with a chlorinating agent in the presence of a solvent and a base, which are both inert to the chlorinating agent.

Process for the selective sulfoxide reduction of 3-hydroxy cephem and

A method for the acylation of the 7-amino group of the cephalosporanic ring, according to which a 7-ACA amino thiazolyl protected adduct is prepared by acylating said amino group by an aminothiazolyl acetic acid whose amino group has been protected by a phenyl acetyl or a phenoxy acetyl group, the amino group being then deprotected by aqueous hydrolysis in the presence of penicillin G amidase or respectively penicillin V amidase.

Method for the acylation of the 7-amino group of the cephalosporanic ring

The invention relates to oxime derivatives of cephalosporanic structure, possessing antibacterial activity.

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Paullo, Italy

Maurizio Zenoni