Archimica S.r.l.

Farmabios S.p.a.

Clariant Life Science Molecules (Italy) S.p.a.

Maurizio Velati

Marco Frigerio

Giorgio Bertolini

Maurizio Deleo

Massimo Losa

Claudio Gianluca Pozzoli

Cristina Manfrotto

Marco Nicolini

Luigi Petrucciani

Andrea Busca

A novel process for preparing emtricitabine, and more particularly a process for preparing emtricitabine involving the formation and isolation of intermediate compounds in salified form, is described.

Process and intermediates for preparing emtricitabine

A process for preparing the [R&#x2014;[R*,R*-(E)]]-2,2'-(1,8-dioxo-4-octene-1,8-diyl) bis(oxy-3,1-propanediyl)bis(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl) methyl]isoquinolinium) dichloride, commonly known as mivacurium chloride, useful as short-duration neuromuscular blocking agent.

Process for the preparation of mivacurium chloride

A process is disclosed for the stereo-selective preparation of emtricitabine, which allows the desired product to be obtained in good yield and without the use of chromatographic techniques. The process for the production of emtricitabine of the formula (Ia) is characterized by the formation and isolation of intermediate compounds of formula (XIa) in salified form. Emtricitabine is a known antiviral drug.

The present invention relates to a process for preparing 5&prime;-acetylstavudine, an intermediate which is useful in the preparation of 2&prime;,3&prime;-didehydro-3&prime;-deoxythymidine, an active principle with antiviral action which is commonly known as stavudine (D4T).

Process for preparing 5&prime;-acetylstavudine

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Mezzana Rabattone, Italy

Maurizio Velati