Plantex Ltd.

Euticals Spa

Archimica S.r.l.

Maurizio Gallina

Marina Ratkaj

Paolo Simone Tiseni

Paolo Angioletti

Giorgio Bertolini

Giuseppe Motta

Domenico Vergani

Solid state forms of Palbociclib dimesylate, processes for preparation thereof and use thereof for preparation of Palbociclib are disclosed.

Solid state forms of palbociclib dimesylate

Solid state forms of Palbociclib dimesylate

A process for preparing fexofenadine is described, which provides for the hydrolysis of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidyl]-1-oxobutyl]-&#x3b1;,&#x3b1;-dimethylbenzeneacetic acid-alkyl ester, in a mixture of water and optionally an organic solvent, in the presence of a base; the carboxylate salt of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidyl]-1-oxobutyl]-&#x3b1;,&#x3b1;-dimethylbenzeneacetic acid is thus obtained, which is then directly reduced as carboxylate in a basic environment with hydrogen in the presence of a suitable hydrogenation catalyst to give the carboxylate of fexofenadine, which is precipitated by neutralization of the solution.

Process for preparing fexofenadine

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Novara, Italy

Maurizio Gallina