Oncoethix Gmbh

Nerviano Medical Sciences S.r.l.

Pharma Mar, S.a.

Maurizio D'Incalci

Dario Ballinari

Enrico Pesenti

Kay Noel

Juergen Moll

Rafaella Giavazzi

Naoto Takahashi

Glynn Thomas c/o Pharmamar Usa Inc Faicloth

Andreas Gescher

Steve c/o Institute For Drug Development Weitman

A method of treating triple-negative breast cancer in a mammal comprising the step of: administering to a patient a pharmaceutical acceptable amount of a compound being a thienotriazolodiazepine compound of the Formula (1) wherein Ris alkyl having a carbon number of 1-4, Ris a hydrogen atom; a halogen atom; or alkyl having a carbon number of 1-4 optionally substituted by a halogen atom or a hydroxyl group, Ris a halogen atom; phenyl optionally substituted by a halogen atom, alkyl having a carbon number of 1-4, alkoxy having a carbon number of 1-4 or cyano; &#x2014;NR&#x2014;(CH)&#x2014;Rwherein Ris a hydrogen atom or alkyl having a carbon number of 1-4, m is an integer of 0-4, and Ris phenyl or pyridyl optionally substituted by a halogen atom; or &#x2014;NR&#x2014;CO&#x2014;(CH)&#x2014;Rwherein Ris a hydrogen atom or alkyl having a carbon number of 1-4, n is an integer of 0-2, and Ris phenyl or pyridyl optionally substituted by a halogen atom, and Ris &#x2014;(CH)&#x2014;CO&#x2014;NH&#x2014;Rwherein a is an integer of 1-4, and Ris alkyl having a carbon number of 1-4; hydroxyalkyl having a carbon number of 1-4; alkoxy having a carbon number of 1-4; or phenyl or pyridyl optionally substituted by alkyl having a carbon number of 1-4, alkoxy having a carbon number of 1-4, amino or a hydroxyl group or &#x2014;(CH)&#x2014;COORwherein b is an integer of 1-4, and Ris alkyl having a carbon number of 1-4, or a pharmaceutically acceptable salt thereof or a hydrate or solvate thereof, in combination with one or more chemotherapy drugs selected from the group consisting of m-TOR inhibitors and mitotic inhibitors.

Method of treating triple-negative breast cancer using thienotriazolodiazepine compounds

Growing community of inventors

Milan, Italy

Maurizio D'Incalci