Genomic Vision

Maurizio Ceppi

Aaron Bensimon

Emmanuel Conseiller

Pierre Walrafen

Jennifer Abscheidt

Jun Komatsu

Etienne Rouleau

Kevin Cheeseman

Methods for detecting the amplifications of sequences in the BRCA1 locus, which sequences have ends consisting of or are framed with sequence stretches present at least twice in the BRCA1 locus, and which amplification results in at least two or at least three, especially three, tandem copies of the amplified sequence; methods for determining a predisposition to diseases or disorders associated with these amplifications, including predisposition to ovarian cancer or breast cancer and methods for detecting amplifications with similar features in other loci.

Methods for the detection of sequence amplification in the BRCA1 locus

A method for detection, visualization and/or comparison of polynucleotide sequences of interest using specially designed sets of long and short probes that enhance resolution and simplify visualization and detection. Probe compositions useful for practicing this method and procedures for identifying useful probes and probe combinations. These methods are useful for the detection of genomic rearrangements, especially those associated with various diseases, disorders and conditions including cancer or for assessment of genomic rearrangements associated with therapy. The probe compositions may be used in kits for detection of genetic rearrangements or in companion diagnostic products or kits, such as kits for the diagnosis or assessment of predisposition to cancer such as colorectal cancer.

Method for identifying or detecting genomic rearrangements in a biological sample

Growing community of inventors

Issy les Moulineaux, France

Maurizio Ceppi