Sanofi

Labaz

Maurice Prost

Michel De Claviere

Peter Polster

The invention relates to novel decahydroquinolinol derivatives represented by the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, in which X represents oxygen or sulphur, R represents an alkyl radical having from 1 to 3 carbon atoms, R.sub.1 represents fluorine, chlorine, bromine or methoxy, R.sub.2 represents hydrogen or methoxy or R.sub.1 and R.sub.2, when they are taken together, represent a 2,3-methylenedioxy or 3,4-methylenedioxy radical. The compounds of the invention are inhibitors of calcium translocation at the level of the cell membrane and are useful more particularly in the treatment of pathological syndromes of the cardiovascular system such as, for instance, angina pectoris.

Novel decahydroquinolinol derivatives, and pharmaceutical compositions

Decahydroquinolinol derivatives corresponding to the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, in which R.sup.1 represents hydrogen, a methyl, ethyl, n-propyl, n-butyl or phenyl radical or a phenyl radical having one substituent or two identical or different substituents selected from chlorine, bromine atoms and a methyl group. Ar represents a phenyl or naphthyl radical or a phenyl radical having one substituent or two identical or different substituents selected from fluorine, chlorine and bromine atoms and methyl, methoxy, acetyl and cyano groups,

Decahydroquinolinol derivatives and methods of treating cardiac

The invention relates to decahydroquinoline derivatives represented by the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R.sup.1 represents an alkyl or alkoxy group, a lower dialkylamino group, an optionally substituted phenyl group, a heterocyclic group; R.sup.2 represents an alkyl group, an optionally substituted phenyl group, a naphthyl group, an unsaturated heterocyclic group, an aralkyl group or an alicyclic group; and R.sup.3 represents a substituted furyl group, an aralkyl group or a group represented by the general formula: ##STR2## wherein A represents an alkylene group; Y represents an oxygen or sulphur atom, a carbonyl, carbonyl-hydroxyimino, carbonyl-hydrazono or sulphoxide group, or a group; ##STR3## n is O or an integer of from 1 to 4, with the proviso that when n is O, Y represents a carbonyl group; and R.sup.4 and R.sup.5, which are identical or different, each represent hydrogen, a halogen atom or a methyl, methoxy or acetyl group. Certain compounds of formula I have been found to possess useful analgesic properties while others have been found to be potentially useful in the treatment of high blood pressure.

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Brussels, Belgium

Maurice Prost